Patent Number: 6,309,889

Title: Nano-grid micro reactor and methods

Abstract: The invention provides exemplary devices and methods to facilitate the performance of assays. In one embodiment, one such device comprises a holding member having a top surface, a bottom surface, and a plurality of holding locations that are adapted to hold at least one article, such as a solid support and/or a cell. When within the holding locations, the articles are preferably disposed below the top surface. A membrane is positioned above the top surface of the holding member, and a pressure system is provided to apply positive pressure to the membrane to force the membrane against the top surface of the holding member. In this way, a seal may be provided between the holding locations.

Inventors: Cutler; Thomas A. (Los Altos Hills, CA), Lalonde; Guy (Woodside, CA), Kelly; Andrew J. G. (Palo Alto, CA), Wagstrom; Christopher R. (Los Altos, CA)

Assignee: Glaxo Wellcome Inc.

International Classification: B01L 3/00 (20060101); B01J 19/00 (20060101); B81B 1/00 (20060101); C12M 1/34 (20060101); G01N 33/50 (20060101); C12Q 001/02 (); C12M 001/34 ()

Expiration Date: 10/30/2018