Patent Number: 6,309,892

Title: Antibodies to components of dense microspheres and methods of using the same

Abstract: DMS present in the brain of individuals susceptible to cerebral amyloidosis disintegrate into DMS components to form cerebral amyloid plaques and other DMS components that are removed from the brain via circulating bodily fluids. Detecting the presence of these removed DMS components and/or antibodies thereto in circulating bodily fluids provides a diagnostic mechanism to determine the onset of cerebral amyloid plaque formation. Detecting the presence of these removed DMS components and/or antibodies thereto in circulating bodily fluids also provides a diagnostic mechanism to determine the efficacy of treatment regimes for preventing cerebral amyloid plaque formation. Antibodies also can be raised against isolated DMS components and subsequently utilized in a diagnostic method capable of detecting the onset of cerebral amyloid plaque formation.

Inventors: Averback; Paul (Beaconsfield, CA)

Assignee: Nymox Pharmaceutical Corporation

International Classification: A61K 31/63 (20060101); A61K 31/70 (20060101); A61K 31/655 (20060101); A61K 31/35 (20060101); A61K 31/40 (20060101); A61K 31/42 (20060101); A61K 31/55 (20060101); A61K 31/505 (20060101); C07H 19/06 (20060101); C07H 19/00 (20060101); C07H 17/00 (20060101); C07H 17/08 (20060101); C07K 14/435 (20060101); C07K 14/47 (20060101); G01N 33/68 (20060101); G01N 33/50 (20060101); G01N 033/53 ()

Expiration Date: 10/30/2018