Patent Number: 6,310,091

Title: Fungicidal saponin, CAY-1, and isolation thereof from Capsium species fruit

Abstract: A novel antifungal compound, "CAY-1", was isolated from the dried fruit of Capsicum frutescens (cayenne pepper), purified to homogeneity, and characterized as a novel sterol glycoside (a saponin) with a molecular mass of 1243.35 Da. CAY-1 demonstrates antifungal activity against a large variety of fungal organisms associated with diseases in plants, animals and humans including, but not limited to, Aspergillus flavus, A. fumigatus, A. parasiticus, A. niger, Pneumocystis carnii and Candida albicans, but has minimal toxic effects on mammalian cells.

Inventors: De Lucca, II; Anthony J. (Metairie, LA), Bland; John M. (Slidell, LA), Vigo; Craig B. (Metairie, LA), Selitrennikoff; Claude P. (Denver, CO)

Assignee: The United States of America as represented by the Secretary of Agriculture

International Classification: A01N 43/90 (20060101); C07J 71/00 (20060101); C07H 15/00 (20060101); C07H 15/256 (20060101); A61K 031/34 (); A61K 031/343 (); C07D 311/96 (); C07D 407/04 ()

Expiration Date: 10/30/2018