Patent Number: 6,310,093

Title: Method of preventing neuronal death

Abstract: Disclosed is a method for preventing neuronal cell death subsequent to an injury to neuronal tissue, particularly central nervous tissue exposed to an ischemic or hypoxic event, to trauma or to a chronic neurodegenerative disorder. The method includes exposing the cells to a glutaminase inhibitor that is relatively impermeant to healthy, intact cell membranes, and which is preferably a specific inhibitor of the form of glutaminase that is widely present in brain tissue.

Inventors: Newcomb; Robert (Palo Alto, CA)

Assignee: Elan Pharmaceuticals, Inc.

International Classification: A61K 31/00 (20060101); A61K 31/185 (20060101); A61K 31/198 (20060101); A61K 031/195 (); A01N 055/06 ()

Expiration Date: 10/30/2018