Patent Number: 6,310,098

Title: Method of treating symptoms of hormonal variation, including hot flashes

Abstract: One aspect of the present invention relates to a method of treating hot flashes in a patient which is carried out by providing a compound which binds a .alpha..sub.2.delta. subunit of a voltage-gated calcium channel and administering the compound to a patient experiencing hot flashes under conditions effective to treat the hot flashes. Another aspect of the present invention relates to a method for treating a symptom of hormonal variation in a patient which is carried out by providing a compound which binds a .alpha..sub.2.delta. subunit of a voltage-gated calcium channel and administering the compound to a patient experiencing a symptom of hormonal variation under conditions effective to treat the symptom of hormonal variation. Further aspects of the present invention relate to the administration of a compound which binds a .alpha..sub.2.delta. subunit of a voltage-gated calcium channel as an anti-pyretic agent (for treating fever) or as an anti-emetic agent (for treating nausea and emesis).

Inventors: Guttuso, Jr.; Thomas J. (Rochester, NY)

Assignee: University of Rochester

International Classification: A61K 31/185 (20060101); A61K 31/195 (20060101); A61K 031/195 ()

Expiration Date: 10/30/2018