Patent Number: 6,310,099

Title: Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives

Abstract: Disclosed are the compounds of formula I ##STR1## wherein R is methyl or ethyl; R.sub.1 is chloro or fluoro; R.sub.2 is hydrogen or fluoro; R.sub.3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R.sub.4 is hydrogen or fluoro; and R.sub.5 is chloro, fluoro, trifluoromethyl or methyl; and pharmaceutically acceptable salts thereof, as selective COX-2 cyclooxygenase inhibitors; and pharmaceutically acceptable prodrug esters thereof.

Inventors: Fujimoto; Roger A. (Morristown, NJ), McQuire; Leslie W. (Warren, NJ), Mugrage; Benjamin B. (Basking Ridge, NJ), van Duzer; John H. (Asbury, NJ), Xu; Daqiang (Whippany, NJ)

Assignee: Novartis Ag

International Classification: C07C 229/42 (20060101); C07C 229/00 (20060101); C07C 229/42 (); A61K 031/196 ()

Expiration Date: 10/30/2018