Patent Number: 6,310,107

Title: Amine compounds, their production and use as amyloid-.beta. production inhibitors

Abstract: A compound of the formula: ##STR1## wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) --S--, --SO-- or --SO.sub.2 --, (iii) C.sub.1-6 alkylene, C.sub.2-6 alkenylene or C.sub.2-6 alkynylene, etc., (iv) --CO--O-- or (v) --(CH.sub.2)p-X.sup.1 --, --(CH.sub.2)p-X.sup.1 -- (CH.sub.2)q-, --(CH.sub.2)r-CO--X.sup.1 --, --SO.sub.2 --NR.sup.8 -- or --(CH.sub.2)r-SO.sub.2 --NR.sup.8 -- wherein X.sup.1 is O or NR.sup.8, R.sup.8 is H, a hydrocarbon group which may be substituted or an acyl, p is 0 to 5, q is 1 to 5, p+q is 1 to 5, and r is 1 to 4; Y is a divalent C.sub.1-6 aliphatic hydrocarbon group optionally containing O or S, which may be substituted; R.sup.1 and R.sup.2 each is H or a lower alkyl which may be substituted, or R.sup.1 and R.sup.2 form a N-containing heterocyclic ring which may be substituted; Ring A is a benzene ring which may be further substituted; and Ring B is a 4- to 8-membered ring which may be further substituted, or a salt thereof has the effect of inhibiting amyloid-.beta. protein production and/or secretion and is useful as a pharmaceutical composition for preventing and/or treating the neurodegenerative disease, etc.

Inventors: Kato; Kaneyoshi (Kawanishi, JP), Terauchi; Jun (Ikeda, JP), Fukumoto; Hiroaki (Suita, JP), Kakihana; Mitsuru (Kobe, JP)

Assignee: Takeda Chemical Industries, Ltd.

International Classification: C07C 217/74 (20060101); C07C 255/54 (20060101); C07C 217/00 (20060101); C07C 255/00 (20060101); C07D 215/14 (20060101); C07D 213/30 (20060101); C07D 213/00 (20060101); C07D 307/00 (20060101); C07D 215/00 (20060101); C07D 333/00 (20060101); C07D 215/20 (20060101); C07D 271/00 (20060101); C07D 307/80 (20060101); C07D 317/00 (20060101); C07D 317/54 (20060101); C07D 295/096 (20060101); C07D 295/00 (20060101); C07D 277/64 (20060101); C07D 215/58 (20060101); C07D 277/00 (20060101); C07D 333/16 (20060101); C07D 271/06 (20060101); A61K 031/137 (); C07C 217/60 ()

Expiration Date: 10/30/2018