Patent Number: 6,310,177

Title: Compounds and methods for modulating tissue permeability

Abstract: Methods for using modulating agents to enhance or inhibit occludin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating agents may be used to increase vasopermeability. The modulating agents comprise at least one occludin cell adhesion recognition sequence or an antibody or fragment thereof that specifically binds the occludin cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.

Inventors: Blaschuk; Orest W. (Westmount, CA), Symonds; James Matthew (Ottawa, CA), Gour; Barbara J. (Kemptville, CA)

Assignee: Adherex Technologies, Inc.

International Classification: C07K 14/435 (20060101); C07K 14/47 (20060101); C07K 14/705 (20060101); A61K 38/00 (20060101); A61K 038/00 (); C07K 005/00 (); C07K 007/00 (); C12N 005/00 ()

Expiration Date: 10/30/2018