Patent Number: 6,310,189

Title: Nucleotides and analogs having photoremoveable protecting groups

Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.

Inventors: Fodor; Stephen P. A. (Palo Alto, CA), Stryer; Lubert (Stanford, CA), Read; J. Leighton (Palo Alto, CA), Pirrung; Michael C. (Durham, NC)

Assignee: Affymetrix, Inc.

International Classification: B01J 19/00 (20060101); C07C 229/14 (20060101); C07C 229/00 (20060101); C07C 229/16 (20060101); C07B 61/00 (20060101); C07H 21/00 (20060101); C07D 263/00 (20060101); C07D 317/62 (20060101); C07D 317/00 (20060101); C07H 19/10 (20060101); C07D 263/44 (20060101); C07K 7/00 (20060101); C07K 7/06 (20060101); C07K 1/00 (20060101); C07K 1/04 (20060101); C07H 19/04 (20060101); C07H 19/00 (20060101); C07K 17/00 (20060101); C07K 17/06 (20060101); C07K 17/14 (20060101); C12Q 1/68 (20060101); G01N 21/64 (20060101); G01N 21/25 (20060101); G03F 7/38 (20060101); G03F 7/26 (20060101); G03F 7/00 (20060101); G11C 13/02 (20060101); C07H 021/00 (); C07H 021/04 (); C07H 021/02 ()

Expiration Date: 10/30/2018