Patent Number: 6,310,191

Title: Generation of diversity in combinatorial libraries

Abstract: The invention concerns gene banks and combinatorial derivatives thereof, prepared using phagemid- or phage-display in combination with type IIS restriction enzymes and cosmid packaging; their use for the isolation of ligands, including enzyme inhibitors, agonists and antagonists for receptors, competitive binding peptides to a defined target, diagnostic ligands for diseases and autoimmune syndromes, including surveillance tools for immune status, post-translationally modified peptides, and such ligands generated by this technology.

Inventors: Collins; John (Braunschweig, DE), Rottgen; Peter (Braunschweig, DE)

Assignee: Cosmix Molecular Biologicals GmbH

International Classification: C12N 15/10 (20060101); C07B 61/00 (20060101); C12N 015/00 (); C07H 021/02 ()

Expiration Date: 10/30/2018