Patent Number: 6,310,192

Title: SigB

Abstract: SigB polypeptides and DNA (RNA) encoding such SigB and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such SigB for the treatment of infection, particularly bacterial infections. Antagonists against such SigB and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of SigB nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding SigB operon and for detecting the polypeptide in a host.

Inventors: Fosberry; Andrew P (Linton, GB), Lawlor; Elizabeth J (Malvern, PA), Nicholas; Richard O (Collegeville, PA)

Assignee: SmithKline Beecham Corporation

International Classification: C07K 14/195 (20060101); C07K 14/31 (20060101); C07H 021/04 (); C12P 021/06 (); C12N 001/20 (); C12N 015/00 ()

Expiration Date: 10/30/2018