Patent Number: 6,310,195

Title: Nucleic acid encoding a lectin-derived progenitor cell preservation factor

Abstract: The invention relates to an isolated nucleic acid molecule that encodes a protein that is effective to preserve progenitor cells, such as hematopoietic progenitor cells. The nucleic acid comprises a sequence defined by SEQ ID NO:1, a homolog thereof, or a fragment thereof. The encoded protein has an amino acid sequence that comprises a sequence defined by SEQ ID NO:2, a homolog thereof, or a fragment thereof that contains an amino acid sequence TNNVLQVT. Methods of using the encoded protein for preserving progenitor cells in vitro, ex vivo, and in vivo are also described. The invention, therefore, include methods such as myeloablation therapies for cancer treatment wherein myeloid reconstitution is facilitated by means of the specified protein. Other therapeutic utilities are also enabled through the invention, for example, expanding progenitor cell populations ex vivo to increase chances of engraftation, improving conditions for transporting and storing progenitor cells, and facilitating gene therapy to treat and cure a broad range of life-threatening hematologic diseases.

Inventors: Colucci; M. Gabriella (Dugenta, IT), Chrispeels; Maarten J. (La Jolla, CA), Moore; Jeffrey G. (New York, NY)

Assignee: ImClone Systems Incorporated

International Classification: C07K 14/415 (20060101); C07K 14/42 (20060101); C12N 5/06 (20060101); C12N 15/90 (20060101); C12N 15/87 (20060101); A61K 35/12 (20060101); C07H 021/04 (); C12N 005/16 ()

Expiration Date: 10/30/2018