Patent Number: 6,310,197

Title: Translation enhancer element of the human amyloid precursor protein gene

Abstract: The present invention is directed to a DNA element that enhances thetranslation of the human amyloid precursor protein (APP) gene. Theenhancer may be incorporated into expression vectors to enhancerecombinant protein production. In addition, the invention is directed toan assay that utilizes vectors containing the translation enhancer elementfor the purpose of identifying agents that modulate the expression of thehuman amyloid precursor protein. These agents will ultimately be used tosuppress APP expression in patients with Alzheimer's disease.

Inventors: Rogers; Jack (Jamaica Plain, MA)


International Classification:

Expiration Date: 10/32013