Patent Number: 6,310,202

Title: Nitric oxide carriers based on polyazamacrocycle complexes

Abstract: Novel compounds capable of carrying and releasing nitrogen oxide (NO) in a biological medium, their use for implementing a therapeutic treatment method or a diagnostic method applied to a human or animal body, and for making medicines useful for treating or preventing disorders affecting the human or animal cardiovascular, nervous, immune, renal or pulmonary system, specifically, an organometallic complex of nitrogen oxide, wherein the cationic part is of the formula (I) ##STR1## in which x=0 or 1; x'=2 or 3; y=0, 2 or 3; z=0 or 1; with the condition that, if y=0 (or z=0) then z=0 (or y=0; respectively); R is a group chosen from the group formed by: a hydrogen atom, --(CH.sub.2).sub.2 COOH and ##STR2## R1, R2, R3 and R4 are groups chosen from the group formed by: a hydrogen atom and alkyl groups comprising from 1 to 4 carbon atoms; and M.sup.2+ is a divalent cation Fe.sup.++ or Co.sup.++.

Inventors: Tabard; Alain (Dijon, FR), Siri; Olivier (Dijon, FR), Cocolios; Panayotis (Bullion, FR), Guilard; Roger (Fontaine Les Dijon, FR)

Assignee: L'Air Liquide, Societe Anonyme pour l'Etude Et l'Exploitation des Procedes Georges Claude

International Classification: C07F 15/02 (20060101); C07F 15/00 (20060101); C07F 15/04 (20060101); C07D 255/02 (); C07D 257/02 ()

Expiration Date: 10/30/2018