Patent Number: 6,310,206

Title: Method for the production of N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides and new intermediate products

Abstract: The invention relates to a process for preparing N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides in which, in a first step, 2-amino-4,5-difluoro-benzonitrile is reacted with sulphonyl halides in the presence of an acid acceptor and in the presence of a diluent at temperatures between 0.degree. C. and 150.degree. C. and, in a second step, the N-(2-cyano-4,5-difluoro-phenyl)-sulphon-amides and/or N-(2-cyano-4,5-difluoro-phenyl)-sulphonamides obtained in the first step are as pure substances or as mixtures with ammonia in the presence of a diluent reacted at a temperature between 100.degree. C. and 200.degree. C. The invention furthermore relates to novel intermediates of the process.

Inventors: Hupperts; Achim (Dusseldorf, DE), Drewes; Mark Wilhelm (Langenfeld, DE), Erdman; David (Liberty, MO), Lantzsch; Reinhard (Wuppertal, DE)

Assignee: Bayer Aktiengesellschaft

International Classification: C07C 311/48 (20060101); C07C 311/00 (20060101); C07C 311/08 (20060101); C07C 255/00 (20060101); C07C 255/58 (20060101); C07C 303/38 (20060101); C07C 303/40 (20060101); C07C 303/00 (20060101); C07C 303/38 (); C07C 303/40 (); C07C 211/52 (); C07C 311/08 (); C07C 311/48 ()

Expiration Date: 10/30/2018