Patent Number: 6,310,212

Title: 4-substituted quinoline derivatives

Abstract: Disclosed are compounds of the Formula I ##STR1## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y.sub.1, and Y.sub.2 are defined herein. These compounds bind with high affinity to GABA.sub.A receptors. Also disclosed are pharmaceutical compositions comprising these compounds, and methods of treating patients suffering from certain central nervous system and peripheral diseases or disorders with these pharmaceutical compositions. This invention also relates to the use of such compounds in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. The compounds of this invention are also useful as probes for the localization of GABA.sub.A receptors.

Inventors: Yuan; Jun (Guilford, CT), Hutchinson; Alan (Madison, CT)

Assignee: Neurogen Corporation

International Classification: C07D 401/04 (20060101); C07D 401/00 (20060101); C07D 487/00 (20060101); C07D 487/04 (20060101); A61K 031/55 (); C07D 215/16 (); C07D 267/02 ()

Expiration Date: 10/30/2018