Patent Number: 6,310,217

Title: Acylpyrroledicarboxylic acids and acylindoledicarboxylic acids and their derivatives as inhibitors of cytosolic phospholipase A2

Abstract: The invention provides novel antiinflammatory and analgesic agents of the formulae ##STR1## The novel compounds have an improved inhibitory effect and/or less cytotoxicity in comparison with compounds known from the prior art. The compounds according to the invention are outstandingly suitable for preventing and/or treating disorders caused or partly caused by an increased activity of the enzyme phospholipase A.sub.2, such as, for example, inflammations, allergies, asthma, psoriasis and endotoxic shock.

Inventors: Lehr; Matthias (Munchen, DE)

Assignee: Merckle GmbH

International Classification: C07D 209/42 (20060101); C07D 207/337 (20060101); C07D 207/416 (20060101); C07D 207/00 (20060101); C07D 209/00 (20060101); C07D 209/10 (); C07D 209/12 (); C07D 209/14 (); C07D 207/32 (); A61K 031/40 (); A61K 031/405 ()

Expiration Date: 10/30/2018