Patent Number: 6,310,221

Title: Methods for synthesis of substituted tetrahydrofuran compound

Abstract: The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1-butynyl)-tetrahydrofuran and precursors thereof.

Inventors: Chorghade; Mukund Shankar (Natick, MA), Gurjar; Mukund Keshao (Pune, IN), Krishna; Palakodety Radha (Hyderabad, IN), Lalitha; Sista Venkata Sai (Sunnyvale, CA), Sadalapure; Kashinath (Dt. Gulbarga, IN), Adhikari; Susanta Sekhar (West Bengal, IN), Murugaiah; Andappan Murugaiah Subbaiah (Tamilnadu, IN), Mhaskar; Sunil Vyankatesh (Natick, MA), Sharma; Gangavaram Vasantha Madhava (Hyderadad, IN), Prasad; Tangallapally Rajendra (Warangal, IN), Sreenivas; Punna (Nalgonda, IN), Reddy; Vavilala Goverdhan (Mahabubnagar, IN), Islam; Aminul (Hyderabad, IN), Prasad; Chittineni Hari (Hyderabad, IN), Rao; Alla Venkata Rama (Hyderabad, IN)

Assignee: Millennium Pharmaceuticals, Inc.

International Classification: C07D 307/14 (20060101); C07D 307/00 (20060101); C07D 307/32 (20060101); C07D 307/12 (20060101); C07D 305/12 ()

Expiration Date: 10/30/2018