Patent Number: 6,310,262

Title: Process for preparing retiferol derivatives

Abstract: A new process prepares retiferol derivatives of formula I: ##STR1## wherein A is --C .ident.C-- or --CH.dbd.CH--, and R.sup.1 and R.sup.2 are independently of each other lower alkyl or lower perfluoroalkyl, one version couples ketones of formula 1I with compounds of formula III A second version couples phosphinoxides of formula IV with aldehydes of formula V. Compounds of formula I are useful in the treatment or prevention of hyperproliferative skin diseases and for reversing the conditions associated with photodamage.

Inventors: Hilpert; Hans (Reinach, CH)

Assignee: Basilea Pharmaceutica AG

International Classification: C07F 7/18 (20060101); C12P 7/62 (20060101); C07C 69/00 (20060101); C07F 7/00 (20060101); C07C 45/00 (20060101); C07C 45/69 (20060101); C07C 45/29 (20060101); C07C 69/013 (20060101); C07C 035/08 ()

Expiration Date: 10/30/2018