Patent Number: 6,333,314

Title: Liposomes containing oligonucleotides

Abstract: It is possible to radiosensitize tumor cells by administration of compositions containing the Human antisense c-raf-1 oligodeoxyribonucleotide (ODN/oligo) sequence: 5'-GTGCTCCATTGATGC-3' (seq. ID No. 1) wherein only the end bases are phosphorylated is a preferred embodiment. Antisense sequences of up to 40 bases which containing this sequence may be used in accord with the teachings of this disclosure. Compositions comprising a cationic liposome of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol may be used as a carrier system. The liposomes provide a new carrier system that is particularly useful for administration of sequences for therapy.

Inventors: Kasid; Usha (Rockville, MD), Gokhale; Prafulla (McLean, VA), Dritschilo; Anatoly (Bethesda, MD), Rahman; Aquilur (Long Grove, IL)

Assignee: Georgetown University School of Medicine

International Classification: A61K 9/127 (20060101); C07H 21/00 (20060101); C12N 15/11 (20060101); A61K 38/00 (20060101); A01N 043/04 (); C12Q 001/68 (); C12P 019/34 (); C12N 015/63 (); C07H 021/04 ()

Expiration Date: 12/25/2018