Patent Number: 6,333,329

Title: 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands

Abstract: Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are the same or different and represent hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.4 alkylthio, hydroxy, amino, mono- or di(C.sub.1 -C.sub.6)alkylamino, cyano, nitro, trifluoromethyl or trifluoromethoxy; and X is oxygen, a bond, C.sub.1 -C.sub.2 alkylene, or methyleneoxy, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.

Inventors: Tran; Jennifer N. (Guilford, CT), Thurkauf; Andrew (Danbury, CT)

Assignee: Neurogen Corporation

International Classification: C07D 307/00 (20060101); C07D 313/04 (20060101); C07D 319/18 (20060101); C07D 313/00 (20060101); C07D 319/00 (20060101); C07D 311/00 (20060101); C07D 307/79 (20060101); C07D 311/04 (20060101); A61K 031/496 ()

Expiration Date: 12/25/2018