Patent Number: 6,333,342

Title: Methods of pharmacological treatment using S(-) amlodipine

Abstract: Methods and compositions are disclosed utilizing the optically pure S(-)isomer of amlodipine. This compound is a potent drug for the treatment ofhypertension while avoiding the concomitant liability of adverse effectsassociated with the administration of the racemic mixture of amlodipine.The S(-) isomer of amlodipine is also useful for the treatment of anginaand such other conditions as may be related to the activity of S(-)amlodipine as a calcium channel antagonist without the concomitantliability of adverse effects associated with the racemic mixture ofamlodipine.

Inventors: Foster; Robert T. (Edmonton, CA)


International Classification: C07D 211/00 (20060101); C07D 211/90 (20060101); A61K 031/44 (); C07D 213/80 (); C07D 213/803 ()

Expiration Date: 12/25/2014