Patent Number: 6,333,350

Title: Use of nitric oxide donors and/or substrates or nitric oxide inhibitors forregulating cervical dilatation and extensibility

Abstract: The invention describes the regulation of cervical dilatation andextensibility by the use of nitric oxide donors and/or substrates ornitric oxide inhibitors. There can be used either(a) at least one nitric oxide donor and/or substrate for manufacture of amedicament to be administered locally intracervically or intravaginallyfor induction of cervical ripening or(b) at least one nitric oxide inhibitor for manufacture of a medicament tobe administered locally intracervically or intravaginally for treatment ofcercvical insufficiency or preterm labor.

Inventors: Chwalisz; Kristof (Berlin, DE), Garfield; Robert E. (Friendswood, TX)


International Classification: A61K 45/00 (20060101); A61K 31/04 (20060101); A61K 31/28 (20060101); A61K 45/06 (20060101); A61K 31/185 (20060101); A61K 31/198 (20060101); A61K 31/223 (20060101); A61K 31/21 (20060101); A61K 31/295 (20060101); A61K 31/34 (20060101); A61K 031/21 (); A61K 031/045 (); A61K 031/195 ()

Expiration Date: 12/25/2014