Patent Number: 6,333,351

Title: N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositionscomprising same, and methods for inhibiting .beta.-amyloid peptide releaseand/or its synthesis by use of such compounds

Abstract: Disclosed are compounds which inhibit .beta.-amyloid peptide release and/orits synthesis, and, accordingly, have utility in treating Alzheimer'sdisease. Also disclosed pharmaceutical compositions comprising a compoundwhich inhibits .beta.-amyloid peptide release and/or its synthesis as wellas methods for treating Alzheimer's disease both prophylactically andtherapeutically with such pharmaceutical compositions.

Inventors: Wu; Jing (San Mateo, CA), Thorsett; Eugene D. (Moss Beach, CA), Nissen; Jeffrey S. (Indianapolis, IN), Mabry; Thomas E. (Indianapolis, IN), Latimer; Lee H. (Oakland, CA), John; Varghese (San Francisco, CA), Fang; Lawrence Y. (Foster City, CA), Audia; James E. (Indianapolis, IN)


International Classification: A61K 31/185 (20060101); A61K 31/198 (20060101); A61K 31/223 (20060101); A61K 31/21 (20060101); A61K 31/275 (20060101); A61K 31/277 (20060101); C07C 229/06 (); A61K 031/24 (); A61K 031/38 (); A61K 031/335 ()

Expiration Date: 12/25/2014