Patent Number: 6,428,997

Title: Aminopeptidase derived from Bacillus licheniformis and process for preparation of natural type proteins

Abstract: The present invention relates to a process for removing methionine (Met) residue at N-terminus of proteins specifically. Particularly, the present invention relates to an aminopeptidase which is purified from Bacillus licheniformis removes a methionine residue from N-terminus of peptide and proteins. And the present invention relates to a process for preparing a natural type protein from proteins produced in microorganisms by recombinant DNA technology. Various kinds of natural type proteins such as human growth hormone (HGH) can be prepared massively and easily by the process of the present invention.

Inventors: Lee; Young-Phil (Taejon-si, KR), Han; Kyuboem (Taejon-si, KR), Kim; Se-Hoon (Taejon-si, KR), Park; Soon-Jae (Taejon-si, KR), Lee; Seung-Joo (Taejon-si, KR)

Assignee: LG Chemical Ltd.

International Classification: C07K 14/435 (20060101); C12N 9/48 (20060101); C07K 14/61 (20060101); C12N 009/56 (); C12P 021/06 (); C07K 001/22 ()

Expiration Date: 08/06/2019