Patent Number: 6,429,195

Title: Aqueous prolonged release formulation

Abstract: Prolonged parenteral release into the circulatory system of a cow of a bioactive growth hormone releasing factor at desirably effective levels can be achieved using novel compositions in which the growth hormone releasing factor is present in an aqueous liquid at a dose of at least about 50 mg and at a concentration of at least about 20 mg/ml. Preferably, the growth hormone releasing factor is present in an aqueous liquid at a dose of about 200 mg and at a concentration of about 180 mg/ml. The aqueous bovine growth hormone releasing factor formulation provides for the sustained release of bovine somatotropin into the circulatory system of the animal for greater than seven (7) days.

Inventors: Foster; Todd P. (Kalamazoo, MI), Moseley; William M. (Augusta, MI), Caputo; James F. (Portage, MI), Hageman; Michael J. (Kalamazoo, MI)

Assignee: Pharmacia & Upjohn Company

International Classification: A61K 38/25 (20060101); A61K 038/00 ()

Expiration Date: 08/06/2010