Patent Number: 6,429,214

Title: Bicyclic antagonists selective for the .alpha.v.beta.3 integrin

Abstract: This invention provides novel bicyclic compounds of Formula (I):##STR1##wherein u, v, m, Y, G, A--B, R.sup.1, R.sup.1a, R.sup.2, R.sup.4, R.sup.5,R.sup.5a, and R.sup.5b are defined in the specification which compoundsexhibit activity as inhibitors of bone resorption and compounds of Formula(II)##STR2##wherein u, v, m, Y, G, D, A--B, R.sup.1, R.sup.1a, R.sup.2, R.sup.3,R.sup.4, R.sup.5, R.sup.5a, and R.sup.5b are defined in the specificationwhich compounds exhibit activity as inhibitors of bone resorption.

Inventors: Zask; Arie (New York, NY), Hauze; Diane Barbara (St. Davids, PA), Kees; Kenneth Lewis (Glenmoore, PA), Coghlan; Richard Dale (Freehold, NJ), Yardley; John (King of Prussia, PA)

Assignee:

International Classification: A61K 31/495 (20060101); A61K 31/5377 (20060101); A61K 31/496 (20060101); A61K 31/541 (20060101); A61K 31/4709 (20060101); A61K 31/537 (20060101); A61K 31/54 (20060101); A61K 31/5375 (20060101); C07D 215/00 (20060101); C07D 215/26 (20060101); C07D 239/14 (20060101); C07D 239/00 (20060101); C07D 215/227 (20060101); A61K 031/47 (); C07D 215/16 ()

Expiration Date: 08/06/2014