Patent Number: 6,429,296

Title: Complex of human growth hormone and zinc and use

Abstract: The present invention provides a complex of human growth hormone and zinc containing human growth hormone and zinc at a molar ratio of about 1:1.6 to about 1:2.4, and a sustained-release preparation which comprises the complex of human growth hormone and zinc and a biodegradable polymer and which has a high entrapment ratio of human growth hormone and exhibits a stable sustained-release suppressing the initial burst.

Inventors: Yamagata; Yutaka (Kobe, JP), Misaki; Masafumi (Takarazuka, JP), Iwasa; Susumu (Kyotanabe, JP)

Assignee: Takeda Chemical Industries, Ltd.

International Classification: A61K 9/16 (20060101); A61K 38/27 (20060101); C07K 14/435 (20060101); C07K 14/61 (20060101); A61K 38/00 (20060101); A61K 038/27 (); A61K 033/30 (); A01N 059/16 ()

Expiration Date: 08/06/2019