Patent Number: 6,440,979

Title: Aryl isoguanines

Abstract: Disclosed are compounds having formula (II): ##STR1## wherein: Q.sub.3, Q.sub.6a, Q.sub.6b and Q.sub.8 are independently a bond, C.sub.1-8 alkylene, C.sub.2-8 alkenylene and C.sub.2-8 alkynylene, and R.sub.3, R.sub.6a, R.sub.6b and R.sub.8 are independently hydrogen, aryl or heteroraryl, optionally substituted by halogen, hydroxy, alkoxy, nitro, cyano and carboxy, provided that: Q.sub.3 R.sub.3 is not hydrogen or methyl. The compounds are effective PDE IV inhibitors and possess improved PDE IV inhibition and improved selectivity with regard to PDE III inhibition.

Inventors: Cavalla; David (Cambridge, GB), Hofer; Peter (Liestal, CH), Chasin; Mark (Manalapan, NJ)

Assignee: Euro-Celtique, S.A.

International Classification: C07D 473/00 (20060101); C07D 473/18 (20060101); C07D 473/22 (20060101); C07D 473/22 (); C07D 473/04 (); C07D 401/04 (); A61K 031/522 (); A61P 011/06 ()

Expiration Date: 08/27/2019