Patent Number: 6,486,232

Title: Bioerodible polymeric semi-interpenetrating network alloys for internal fixation devices and bone cements

Abstract: A bioerodible polymeric material, and in particular a semi-interpenetrating network ("semi-IPN") alloy, is disclosed. A beneficial end use of this material is in the form of internal fixation devices (IFDs) (such as bone supports, plates, and pins) and as cured bone cements for bone repair. A multi-part bioerodible cement system, which, upon mixing of the system parts, forms a cured bioerodible cement, includes, in one part, a first bioerodible polymer (e.g., PLGA) capable of producing acidic products upon hydrolytic degradation, and, in another part, a second bioerodible scaffolding polymer (e.g., PPF) which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for the cured cement. In another aspect, a bone cement system of the invention includes a bioerodible scaffolding polymer (such as PPF), which when polymerized provides a hardened bone cement, the cement system further including a gas generating agent in stabilized form for providing the cured bone cement with pores for facilitating inward cell migration.

Inventors: Wise; Donald L. (Belmont, MA), Gresser; Joseph D. (Brookline, MA), Trantolo; Debra J. (Princeton, MA), Hsu; Yung-Yueh (Acton, MA)

Assignee: Cambridge Scientific, Inc.

International Classification: A61B 17/68 (20060101); A61B 17/86 (20060101); A61L 27/58 (20060101); A61L 27/48 (20060101); A61L 27/00 (20060101); A61L 27/26 (20060101); C08L 11/00 (20060101); A61B 17/80 (20060101); A61F 2/00 (20060101); A61F 2/02 (20060101); A61F 2/28 (20060101); A61F 2/30 (20060101); A61F 2/46 (20060101); A61B 17/00 (20060101); A61L 024/08 ()

Expiration Date: 11/26/2019