Patent Number: 6,486,672

Title: High-resolution NMR spectroscopy of molecules encapsulated in low-viscosity fluids

Abstract: The present invention provides a method for reducing the correlation time for global tumbling for analysis of proteins and other macromolecules by NMR spectroscopy. The method comprises placing a macromolecule, hydrated and without significant structure perturbation, within a reverse micelle in a suitable fluid medium of low viscosity. A high pressure NMR cell for use with the method of the present invention is also disclosed.

Inventors: Wand; A. Joshua (Wallingford, PA), Ehrhardt; Mark R. (Eugene, OR), Flynn; Peter F. (Wallingford, PA)


International Classification: B01L 3/00 (20060101); G01R 33/30 (20060101); G01V 003/00 ()

Expiration Date: 11/26/2019