Patent Number: 6,490,533

Title: System, method, and product for dynamic noise reduction in scanning of biological materials

Abstract: Systems and methods are described for processing an emission signal, such as a fluorescent signal, to compensate for noise in an excitation beam, such as a laser beam. As one example, a scanning system is described that includes an excitation signal generator that provides an excitation signal having one or more representative excitation values representative of an excitation beam; an excitation reference provider that provides at least one excitation reference value; a normalization factor generator that compares the excitation reference value to at least one representative excitation value, thereby generating a normalization factor; and a comparison processor that adjusts at least one emission value corresponding to the at least one representative excitation value based, at least in part, on the normalization factor.

Inventors: Weiner; Nathan K. (Stoughton, MA), Honkanen; Peter D. (Arlington, MA), Woolaver; Timothy J. (Billerica, MA)

Assignee: Affymetrix, Inc.

International Classification: G01N 27/447 (20060101); G01N 21/64 (20060101); G01N 35/00 (20060101); G06F 19/00 (20060101); G01N 35/04 (20060101); G06F 019/00 (); G01N 031/00 ()

Expiration Date: 12/03/2019