Patent Number: 6,512,100

Title: Chromogenic substrates of sialidase and methods of making and using the same

Abstract: The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.

Inventors: Johnson; Stephen C (Birmingham, AL), Saeed; Ashraf (Birmingham, AL), Luo; Ming (Birmingham, AL)

Assignee: Ibbex, Inc.

International Classification: C07H 7/00 (20060101); C07H 7/027 (20060101); C07H 17/02 (20060101); C07H 15/00 (20060101); C07H 17/075 (20060101); C07H 17/00 (20060101); C07H 15/24 (20060101); C07H 15/203 (20060101); C07H 015/04 (); C07H 017/04 ()

Expiration Date: 01/28/2020