Patent Number: 6,512,102

Title: Compositions and methods of diagnosis and treatment using casein kinase I

Abstract: The invention is generally directed to compositions and methods for affecting signal transduction using the casein kinase I (CKI) gene or gene product. The invention is more specifically directed to affecting the Wnt signal pathway using the CKI gene or gene product. The invention is particularly directed to using the CKI gene or gene product to treat and diagnose cancer, particularly breast and colon cancer. CKI.epsilon. is the preferred species. The field of the invention is compositions and methods for modulating signal transduction using the (CKI) gene or gene products and variants thereof. The invention is more specifically directed to modulating the Wnt signal pathway using the CKI gene or gene product. The invention is particularly directed to using the CKI gene or gene product to treat and diagnose disorders mediated by the Wnt signal pathway, especially hyperproliferative disorders, particularly breast and colon cancer.

Inventors: Xu; Licen (Fremont, CA), Harrison; Stephen D. (Albany, CA), Williams; Lewis T. (Mill Valley, CA)

Assignee: Chiron Corporation

International Classification: A61K 38/45 (20060101); A61K 38/43 (20060101); A61K 31/00 (20060101); C12N 15/11 (20060101); A61K 38/00 (20060101); A61K 48/00 (20060101); C07H 021/04 ()

Expiration Date: 01/28/2020