Patent Number: 6,512,161

Title: Transgenic rabbit that expresses a functional human lipoprotein (a)

Abstract: A transgenic rabbit which has in its genomic DNA sequences that encode apolipoprotein (a) and apolipoprotein B polypeptides which are capable of combining to produce lipoprotein (a), a process for creating such a rabbit, and the use of the rabbit to identify compounds which are effective in the treatment of human diseases which are associated with, induced and/or exacerbated by Lp(a) expression.

Inventors: Rouy; Didier (Thiais, FR), Duverger; Nicolas (Paris, FR), Emmanuel; Florence (Aubervilliers, FR), Denefle; Patrice (Saint Maur, FR), Houdebine; Louis-Marie (Buc, FR), Viglietta; Celine (Versailles, FR), Rubin; Edward M. (Berkeley, CA), Hughes; Steven D. (Oakland, CA)

Assignee: Aventis Pharmaceuticals, Inc.

International Classification: C07K 14/435 (20060101); C07K 14/775 (20060101); C12N 15/85 (20060101); G01N 033/00 (); A01K 067/00 (); A01K 067/027 (); C12N 015/00 ()

Expiration Date: 01/28/2020