Patent Number: 6,514,995

Title: Enediyne compounds and methods related thereto

Abstract: The invention provides novel tetradentate enediyne ligands that are themselves thermally stable, yet react at about room temperature or slightly higher upon addition of metal ions or under photothermal conditions. In another aspect of the invention, a method of treating a disorder in a mammal comprising administering a therapeutically effective amount of a compound or composition is provided. In addition, the free ligand can be delivered to the mammal prior to complexation to metals, such that the ligand is exposed to a metal in the body and forms a metal complex in vivo. Furthermore, a metal complex of the invention can be administered to the mammal such that the complex exchanges the first metal center with another endogenous metal in order to form a second metal complex in vivo. The second metal complex is capable of forming a benzenoid diradical under physiological conditions and/or under photothermal conditions.

Inventors: Zaleski; Jeffrey M. (Bloomington, IN), Rawat; Diwan Singh (Bloomington, IN)

Assignee: Advanced Research and Technology Institute, Inc.

International Classification: C07C 217/90 (20060101); C07C 217/92 (20060101); C07C 217/88 (20060101); C07C 215/00 (20060101); C07C 217/00 (20060101); C07C 323/00 (20060101); C07C 323/19 (20060101); C07D 213/00 (20060101); C07C 217/84 (20060101); C07C 215/76 (20060101); C07D 213/53 (20060101); C07D 213/74 (20060101); A61K 031/44 (); C07D 401/12 ()

Expiration Date: 02/04/2011