Patent Number: 6,528,809

Title: Methods and apparatus for tailoring spectroscopic calibration models

Abstract: A method and apparatus for non-invasively measuring a biological attribute,such as the concentration of an analyte, particularly a blood analyte intissue such as glucose. The method utilizes spectrographic techniques inconjunction with an improved subject-tailored calibration model. In acalibration phase, calibration model data is modified to reduce oreliminate subject-specific attributes, resulting in a calibration data setmodeling within- subject physiological variation, sample location,insertion variations, and instrument variation. In a prediction phase, theprediction process is tailored for each target subject separately using aminimal number of spectral measurements from each subject.

Inventors: Thomas; Edward V. (Albuquerque, NM), Rowe; Robert K. (Corrales, NM)


International Classification: A61B 5/00 (20060101); G01N 21/31 (20060101); G01N 21/35 (20060101); G01J 3/28 (20060101); G01N 015/06 ()

Expiration Date: 03/02015