Patent Number: 6,617,322

Title: Preferentially substituted calcium channel blockers

Abstract: Compounds of the formula##STR1##and their salts,wherein Cy represents cyclohexyl;Y is CH.dbd.CH.PHI., CH.PHI..sub.2, .PHI. or Cy,X is trivalent straight-chain alkylene (3-10C) or trivalent straight-chain1-alkenylene (3-10C) optionally substituted by oxo at the C adjacent Nwhen n is 0 and Y is .PHI..sub.2 CH; and is otherwise trivalentstraight-chain alkylene (5-10C) or trivalent straight-chain 1-alkenylene(5-10C) optionally substituted by oxo at the C adjacent N;Z is N, NCO, CHNCOR.sup.1 or CHNR.sup.1, wherein R.sup.1 is alkyl (1-6C);andn is 0-5;wherein each .PHI. and Cy independently may optionally be substituted byalkyl (1-6C) or by halo, CF.sub.3, OCF.sub.3, NO.sub.2, NR.sub.2, OR, SR,COR, COOR, CONR.sub.2, NROCR or OOCR where R is H or alkyl (1-4C), or twosubstituents may form a 5-7 membered ringwith the proviso that the compounds of formula (1) contain at least onearomatic moiety,are useful as calcium channel blockers.

Inventors: Snutch; Terrance P. (Vancouver, CA)

Assignee:

International Classification: A61K 31/5375 (20060101); A61K 31/495 (20060101); A61K 31/506 (20060101); A61K 31/4468 (20060101); A61K 31/4545 (20060101); A61K 31/4515 (20060101); A61K 31/454 (20060101); A61K 31/496 (20060101); A61K 31/451 (20060101); A61K 31/4523 (20060101); C07D 295/185 (20060101); C07D 211/00 (20060101); C07D 211/58 (20060101); C07D 317/60 (20060101); C07D 211/46 (20060101); C07D 211/16 (20060101); C07D 211/14 (20060101); C07D 317/00 (20060101); C07D 401/04 (20060101); C07D 401/14 (20060101); C07D 401/00 (20060101); C07D 295/03 (20060101); C07D 295/00 (20060101); A61K 031/535 (); A61K 031/495 (); A61K 031/445 ()

Expiration Date: 09/02015