Patent Number: 6,617,326

Title: Imidazo-triazine derivatives as ligands for GABA receptors

Abstract: A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by a (cyano)(fluoro)phenyl moiety, being selective ligands for GABA.sub.A receptors, in particular having good affinity for the .alpha.2 and/or .alpha.3 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety and convulsions.

Inventors: Carling; William Robert (Bishops Stortford, GB), Hallett; David James (Watford, GB), Russell; Michael Geoffrey Neil (Welwyn Garden City, GB), Street; Leslie Joseph (Little Hallingbury, GB)

Assignee: Merck Sharp & Dohme Ltd.

International Classification: C07D 487/00 (20060101); C07D 487/04 (20060101); C07D 487/04 (); A61K 031/53 ()

Expiration Date: 09/09/2011