Patent Number: 6,617,438

Title: Oligoribonucleotides with enzymatic activity

Abstract: Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.

Inventors: Beigelman; Leonid (Broomfield, CO), Burgin; Alex B. (Chula Vista, CA), Beaudry; Amber (Broomfield, CO), Karpeisky; Alexander (Lafayette, CO), Matulic-Adamic; Jasenka (Boulder, CO), Sweedler; David (Louisville, CO), Zinnen; Shawn (Denver, CO)

Assignee: Sirna Therapeutics, Inc.

International Classification: C07H 21/00 (20060101); C07H 19/10 (20060101); C07H 19/20 (20060101); C07H 19/00 (20060101); C12P 19/30 (20060101); C12P 19/00 (20060101); C12N 15/11 (20060101); A61K 38/00 (20060101); C07H 021/02 ()

Expiration Date: 09/09/2020