Patent Number: 6,617,450

Title: P-glycoproteins and uses thereof

Abstract: The invention pertains to cynomologous monkey P-glycoproteins and relatedP-glycoproteins which include cynomologous-specific amino acids, as wellas nucleic acids which encode those polypeptides. The present inventionalso includes fragments and biologically functional variants of thecynomologous monkey P-glycoprotein. The invention further relates tomethods of using such cynomologous monkey P-glycoprotein nucleic acids andpolypeptides, especially in methods for determining bioavailability ofdrugs and for screening for inhibitors of cynomologous PGP. Also includedare cynomologous PGP inhibitors which inhibit cynomologous PGP activity byinhibiting the expression or function of cynomologous PGP.

Inventors: Stocker; Penny J. (Jamaica Plain, MA), Steimel-Crespi; Dorothy T. (Marblehead, MA), Crespi; Charles L. (Marblehead, MA)


International Classification: C07K 14/435 (20060101); C07K 14/705 (20060101); C07H 021/04 (); C07K 001/00 (); C07K 014/00 (); C07K 017/00 (); C12N 001/20 (); C12N 015/00 (); C12N 015/09 (); C12N 015/63 (); C12N 015/70 (); C12N 015/74 ()

Expiration Date: 09/02015