Patent Number: 6,761,878

Title: Pathological tissue detection and treatment employing targeted benzoindole optical agents

Abstract: Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management.

Inventors: Achilefu; Samuel (St. Louis, MO), Dorshow; Richard B. (St. Louis, MO), Rajagopalan; Raghavan (Woodmere Village, OH), Bugaj; Joseph E. (St. Charles, MO)

Assignee: Mallinckrodt, Inc.

International Classification: A61K 41/00 (20060101); A61K 49/00 (20060101); C07D 209/00 (20060101); C07D 209/60 (20060101); C09B 23/08 (20060101); C09B 23/00 (20060101); A61B 010/00 (); A61B 005/00 (); A61B 008/00 ()

Expiration Date: 07/12012