Patent Number: 6,761,884

Title: Vectors including foreign genes and negative selective markers

Abstract: A vector, in particular a retroviral vector, which includes a heterologous or foreign gene and a gene encoding a negative selective marker. The negative selective marker enables one to kill cells which contain the gene encoding the negative selective marker, when a particular agent is administered to such cells.

Inventors: Blaese; Michael (Rockville, MD), Anderson; W. French (Bethesda, MD), McLachlin; Jeanne R. (Watkinsville, GA), Chiang; Yawen L. (Potomac, MD), Eglitis; Martin (Kensington, MD)

Assignee: The United States of America as represented by the Department of Health and Human Services

International Classification: C12N 15/867 (20060101); A61K 048/00 (); C12N 005/10 ()

Expiration Date: 07/12012