Patent Number: 6,761,887

Title: Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells

Abstract: Disclosed are a composition of chemically defined components which support in vitro and in vivo chondrogenesis of mesenchymal stem cells, a method for in vitro and in vivo chondrogenic induction of such stem cells, and a method of forming human chondrocytes in vitro and in vivo from such stem cells.

Inventors: Kavalkovich; Karl (Baltimore, MD), Boynton; Raymond (Watertown, MA), Murphy; Mary (Baltimore, MD), Barry; Frank (Baltimore, MD)

Assignee: Osiris Therapeutics, Inc.

International Classification: A61L 27/00 (20060101); A61L 27/38 (20060101); A61L 27/52 (20060101); A61L 27/20 (20060101); C12N 5/06 (20060101); C12N 011/10 (); C12N 011/04 (); C12N 005/06 (); C12N 005/08 ()

Expiration Date: 07/13/2021