Patent Number: 6,762,029

Title: Methods of identifying agents that modulate P2Y12 receptor activity

Abstract: The present invention includes a novel subtype of the P2-purinergic receptor, referred to as the P2Y.sub.12 receptor. This receptor is expressed selectively in the platelets and brain, and couples to a pertussis toxin-sensitive G protein (Gi). Nucleic acids encoding the receptor and associated screening and therapeutic methods are also disclosed.

Inventors: Conley; Pamela B. (Palo Alto, CA), Jantzen; Hans-Michael (San Francisco, CA), Ramakrishnan-DuBridge; Vanitha (Belmont, CA), Julius; David Jay (San Francisco, CA), Hollopeter; Gunther (San Francisco, CA)

Assignee: Portola Pharmaceuticals, Inc.

International Classification: C07K 14/435 (20060101); C07K 14/705 (20060101); G01N 33/50 (20060101); G01N 33/74 (20060101); G01N 033/53 (); G01N 033/567 (); C07K 014/00 (); C07H 021/04 ()

Expiration Date: 07/12016