Patent Number: 6,762,184

Title: Inhibition of matrix metalloproteases by substituted biaryl oxobutyric acids

Abstract: This application relates to matrix metalloprotease inhibitors having the generalized formula ##STR1##in which r is 0-2, T is selected from ##STR2##and R.sup.40 is a mono-or bi-heterocyclic structure. More particularly, the present application claims the various stereoisomeric forms of 4-(4'-choloro-biphenyl-4-yl)-4-oxo-2-[2-(4-oxo-4H-benzo[d][1,2,3]triazin-3 -yl)ethyl]butyric acid, as well as their pharmaceutically acceptable salts. Pharmaceutical compositions containing these compounds, and methods for inhibiting matrix metalloprotease activity in mammals such as humans and for treating various conditions by administering such compounds are also claimed.

Inventors: VanZandt; Michael C. (Guilford, CT), Brittelli; David R. (Branford, CT), Dixon; Brian R. (Woodbridge, CT)

Assignee: Bayer Pharmaceuticals Corporation

International Classification: C07D 253/08 (20060101); C07D 237/00 (20060101); C07D 237/32 (20060101); C07D 253/00 (20060101); C07C 62/00 (20060101); C07C 62/38 (20060101); A61K 031/53 (); C07D 253/08 ()

Expiration Date: 07/12012