Patent Number: 6,762,188

Title: Pharmaceutically active benzoquinazoline compounds

Abstract: Compounds of formula (I) or salts thereof, wherein the dotted Line represents a single or double bond, R.sup.1 is alkyl or amino optionally substituted by alkyl, alkanoyl or benzyl group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and each is selected from hydrogen, phenyl, halo, nitro, a group S(O).sub.n R.sup.8 wherein n is the integer 0, 1 or 2 and R.sup.8 is halo or alkyl or a group NR.sup.9 R.sup.10 wherein R.sup.9 and R.sup.10 are both hydrogen, a group NR.sup.11 R.sup.12 wherein R.sup.11 and R.sup.12 are the same or different and each is hydrogen or alkyl, a group OR.sup.13 wherein R.sup.13 is hydrogen or C.sub.1-4 of alkyl optionally substituted by halo; a C.sub.1-4 aliphatic group optionally substituted by a group OR.sup.14 or NR.sup.14 R.sup.15 wherein R.sup.14 and R.sup.15 are the same or different and each is hydrogen or alkyl; or two of R.sup.2 to R.sup.5 are linked together to form a benzo group, or one of R.sup.2 to R.sup.5 is a group X--Y--R.sup.16 wherein X is CH.sub.2, NR.sup.17, CO or S(O).sub.m and Y is CH.sub.2, NR.sup.17, O or S(O).sub.m, or X--Y is O, NR.sup.17, --CH.dbd.CH-- or N.dbd.N--, are disclosed as pharmacological agents useful in the treatment of tumours. Pharmaceutical compositions and methods for the preparation of compounds of formula (I) are also described.

Inventors: Pendergast; William (Durham, NC), Dickerson; Scott Howard (Chapel Hill, NC), Johnson; Julius Vass (Chapel Hill, NC), Ferone; Robert (Raleigh, NC)

Assignee: SmithKline Beecham Corporation

International Classification: C07D 239/70 (20060101); C07D 239/00 (20060101); C07D 403/12 (20060101); C07D 403/00 (20060101); A61K 031/502 ()

Expiration Date: 07/12012