Patent Number: 6,762,291

Title: Insect p53 tumor suppressor genes and proteins

Abstract: A family of p53 tumor suppressor nucleic acid and protein isolated from several insect species is described. The p53 nucleic acid and protein can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in p53 expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds that are potential pesticidal agents or therapeutics that interact with p53 protein. They can also be used in methods for studying p53 activity and identifying other genes that modulate the function of, or interact with, the p53 gene. Nucleic acid and protein sequences for Drosophila p33 and Rb tumor suppressors are also described.

Inventors: Buchman; Andrew Roy (Berkeley, CA), Platt; Darren Mark (San Francisco, CA), Ollman; Michael Martin (Menlo Park, CA), Young; Lynn Marie (Redwood City, CA), Demsky; Madelyn Robin (San Francisco, CA), Keegan; Kevin Patrick (San Lorenzo, CA), Friedman; Lori (San Francisco, CA), Kopczynski; Casey (Belmont, CA), Larson; Jeffrey S. (Burlingame, CA), Robertson; Stephanie A. (San Francisco, CA)

Assignee: Exelixis, Inc.

International Classification: C07K 14/435 (20060101); C07K 14/47 (20060101); C12Q 001/68 (); C07H 021/04 ()

Expiration Date: 07/12016