Patent Number: 6,762,307

Title: Method for the preparation of citalopram

Abstract: The present invention relates to a method for the preparation of citalopram or any of its enantiomers and acid addition salts thereof comprising reaction of a compound of formula II ##STR1##with a diene having the formula ##STR2##wherein X is O, S, SO.sub.2, --N.dbd.N--, --CO--O--, --O--CO--, oror with a diene having the formula ##STR3##wherein R is alkyl or optionally substituted aryl or arylalkyl.The invention also relates to intermediates used in the new process for the preparation of citalopram, as well as citalopram prepared according to the new process.

Inventors: Petersen; Hans (Vanl.o slashed.se, DK), Felding; Jakob (Charlottenlund, DK)

Assignee: H. Lundbeck A/S

International Classification: C07C 215/00 (20060101); C07C 215/34 (20060101); C07D 307/00 (20060101); C07D 307/28 (20060101); C07D 307/87 (20060101); C07D 307/78 (); C07D 307/87 (); C07D 217/00 ()

Expiration Date: 07/12012