Patent Number: 6,762,320

Title: N-acylamino benzyl ether derivatives

Abstract: This invention relates to N-acylamino aryl derivatives of the formula ##STR1## where R.sup.1, R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.3, R.sup.4, R.sup.5 R.sup.6, R.sup.7, R.sup.8, R, and n are as defined herein and where X is --CHRO, --OCHR--, --CH.sub.2 S--, --SCH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH-- or --C.ident.C--. The compounds of the invention are selective monoamine oxidase B inhibitors, and they are therefore useful in the treatment of diseases mediated by monoamine oxidase B, for example, for the treatment of Alzheimer's disease or senile dementia.

Inventors: Jolidon; Synese (Blauen, CH), Sarmiento; Rosa Maria Rodriguez (Basel, CH), Thomas; Andrew William (Birsfelden, CH), Wyler; Rene (Zurich, CH)

Assignee: Hoffman-La Roche Inc.

International Classification: C07C 233/00 (20060101); C07C 237/04 (20060101); C07C 243/14 (20060101); C07C 255/00 (20060101); C07C 237/00 (20060101); C07C 243/00 (20060101); C07C 233/25 (20060101); C07C 235/00 (20060101); C07C 233/33 (20060101); C07C 255/23 (20060101); C07C 233/60 (20060101); C07C 233/15 (20060101); C07C 235/16 (20060101); C07C 237/22 (20060101); C07C 259/00 (20060101); C07C 259/06 (20060101); C07C 233/05 (); A61K 031/16 ()

Expiration Date: 07/13/2021